An introductory biochemistry course covering the fundamental concepts of protein structure and function as well as metabolism of carbohydrates, lipids and amino acids. The focus will be on energy transactions in a physiological context including glucose homeostasis and muscle metabolism in mammals. A lecture and problem-based tutorial course involving specific case studies will be complemented by a hands-on laboratory course.
An introductory biochemistry course covering the fundamental concepts of protein structure and function as well as metabolism of carbohydrates, lipids and amino acids. The focus will be on energy transactions in a physiological context including glucose homeostasis and muscle metabolism in mammals. A lecture and problem-based tutorial course will be complemented by case studies relevant to animal health and disease.
Concepts of protein function, post-translational modification, folding, targeting and turn-over. The relationship between macromolecular structure/function and cell structure/function is explored with studies of cell membranes, the cell cytoskeletal, extracellular matrix and organelle organisation and function. Protein structure-function relationships will be discussed and analysed in the context of enzyme kinetics, enzyme catalysis and regulation.
Energy metabolism in higher eukaryotes from the perspective of life on earth and the necessary adaptation of living organisms from an anaerobic to aerobic environment. Carbohydrate, lipid and nitrogen metabolism in the context of health and disease. Integration and regulation of carbohydrate, lipid and amino acid metabolism. A lecture and problem-based tutorial course complemented by a hands-on project-based laboratory course.
A foundation course that introduces molecular aspects of the cellular processes occurring in humans, animals, microbes and plants. An exploration of the molecules of life, proteins and enzymes in action, energy for living and energy storage with applications to the environment, health and disease, biotechnology, nutrition, sport and exercise. Theoretical aspects are supported by a laboratory programme focused on proteins and enzymes and their uses in diagnosing disease.
Structure of DNA. Replication, DNA repair and transcription. Regulation of prokaryotic gene expression. Technologies used in the study of genes and gene expression: plasmids, sequencing, restriction enzymes, libraries, PCR, Southern, northern and western analysis, expression vectors and the production of recombinant proteins. A practical course that illustrates concepts presented in the lectures.
Protein biosynthesis, structure and function. Topics will include protein translation, folding, targeting and post-translational modification, the relationship between protein structure and function, enzyme kinetics, mechanisms of enzyme catalysis and control, membranes and membrane proteins. Lectures will be complemented with a practical course focused on developing the appropriate skills to investigate proteins.
Energy metabolism. Biosynthesis of carbohydrates and the metabolism of polysaccharides. Lipid metabolism. Nitrogen metabolism. Integration and regulation of carbohydrate, lipid and amino acid metabolism. Cellular communication systems.
The molecular mechanisms responsible for the signalling and biochemical responses of cells with a particular focus on protein structure and function. The course explores current methods of protein analysis, advanced studies in protein structure and function, cell signalling and cellular processes.
An advanced course on gene regulation. Topics include methods and experimental strategies for studying gene promoters and associated transcription factors, transcription initiation, transcription activation, role of chromatin structure in gene regulation, RNA processing, the role of non-coding RNA in gene expression and cytoplasmic control mechanisms.
The structural and biochemical basis of protein function will be explored with an emphasis on techniques of protein isolation and purification, current methods of protein analysis, enzyme function and kinetics, protein folding and molecular interactions. A laboratory and computer-based practical course in protein purification and analysis reinforces the theoretical aspects of the course.