A general course on methods and applications of genetic analysis. Topics include genetic variation, cytogenetics, gene inheritance, gene mapping, gene function, quantitative genetics, population genetics and evolution, cell and developmental biology.
Aspects of genetics that are important in human biology. Topics include chromosome abnormalities, genes and genetic disease, immunogenetics, cancer, ageing, complex traits, family studies and populations.
This fundamental course for the biological sciences explores the genetic principles and evolutionary processes important for understanding the relationships among genetic diversity, phenotype variation, and biological evolution. Topics include sources of molecular genetic variation, the genetic basis of traits with simple and complex patterns of inheritance, evolutionary mechanisms and patterns, and molecular evolution.
The molecular genetics of health and disease. Topics include DNA structure, replication and repair, gene structure and gene expression. Methods used to study and manipulate genes will be explored, and these concepts applied to understanding the molecular basis of disease, diagnostic testing and development of modern treatment strategies. A lecture and problem-based course, complemented by practical laboratory experience.
An introductory course on the principles and applications of genetics, with an emphasis on problem solving. Students will review the topics of gene structure and function before they learn about how genetic variation and genetic inheritance affect populations of organisms. Students will be introduced to the details of cellular genetics and chromosome structure, location and function. Students will be given tools that will allow them to consider population genetics, quantitative genetics, genomics and an overview of both classic and modern methods of genetic analysis.
A course on molecular biology including the structure of DNA, its replication, how DNA is repaired when damaged, and how genes are expressed to make proteins in prokaryotic and eukaryotic cells. Topics such as protein transport, protein structure and function, signal transduction, and epigenetics will also be covered. Students will do practical course work that complements and illustrates concepts presented in the lectures.
DNA structure, topology and recombination. The contributions of bacteriophage to DNA technology. Advanced applications of DNA sequencing, gene cloning, PCR, microarrays and gene targeting, including molecular diagnostics of genetic disorders. Practical experience will be gained with DNA quantification, molecular cloning, PCR, DNA sequencing, molecular diagnostics of genetic disorders, computer analysis and expression of heterologous genes.
An advanced course in laboratory techniques used in Genetics. Emphasis is on understanding the theory behind the methods used, on data evaluation and on the application of genetic techniques to various questions in biology. Practicals include microarray analysis, transposon tagging, human microsatellite and SNP analysis and reporter gene expression.
A course with a strong emphasis on the structure and function of mammalian cells. Topics covered include chromosome structure and function, cell cycle, signal transduction, cytoskeleton and molecular motors, cell adhesions and interactions, cell motility, stem cells and their biomedical potential, cell death and cancer. The practical component has a strong emphasis on biochemical, genetic and microscopic methods that are used to study eukaryotic cells.
Applications of molecular genetics, genomics and sequence analysis. Topics will include gene cloning, PCR, gene targeting, recombination, transposons, transgenes and mutagenesis using state-of-the-art technologies (CRISPR, gene drives). Students will gain practical experience by planning and performing a DNA technology project encompassing primer design, PCR, molecular cloning, DNA quantification, electrophoresis, DNA sequencing and computer analysis of the recombinant construct.
This advanced course focuses on the practical computational skills needed to extract biological information from genomes and associated 'omics systems, including transcriptomes and metagenomes. This course spans topics including the dynamic nature of the genome through to sequence analysis, curation, annotation and data visualisation.
An interactive and self-directed learning approach will be used to explore the analysis of genomes, transcriptomes and metagenomes. The emphasis will be on understanding and applying a range of practical methodologies to extract biologically significant information from large genetic data sets.
A course on the advanced methods and applications of molecular biology in academia, agriculture, and industry to address topics ranging from pollution to disease. Topics include cutting edge techniques in molecular biology including CRISPR, gene editing and cloning, protein engineering, genomics, and synthetic biology, with an emphasis on examples from New Zealand. Students will do practical course work that complements and illustrates concepts presented in the lectures.
A course on understanding organisms at the level of the genome (the genes), the proteome (the proteins), and the population. Methods in understanding the structure, function, and evolution of the genome and proteome will be discussed. Students will be introduced to methods of computational analysis of genomic data by analysing real biological data. The introduction to computational analysis is geared towards biologists and assumes no previous knowledge or familiarity with computational methods.
Regulation of gene expression including chromatin structure, transcription factors, modulation of transcription (e.g. immunoglobulin genes) and post-transcriptional control mechanisms. Signal transduction, protein structure and function as it relates to proton pumps, catalytic strategies, translation and protein sorting. The structural organization of the cytoskeleton, knowledge of cell adhesion and the extracellular matrix, cell signalling mechanisms, cell cycles and vesicular transport.
203.343 Genetics of Human Health and Ancestry15 credits
The use of genetics and genomics to solve modern problems in biology with an emphasis on humans; exploration of the use of genetic, genomic and epigenetic data to understand human ancestry and health, and in forensics. Students will have the opportunity to sequence their own DNA and investigate ethical and genetic counselling issues related to personal genomic data.
An advanced course based on current literature where genetic approaches are used to understand important biological processes. Topics will include DNA recombination, plant-microbe symbiosis, plant-fungal gene interactions, the genetic basis of learning and memory and epigenetics.