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Doctor of Philosophy, (Chemistry)
Study Completed: 2009
College of Sciences
Synthetic targets as mechanistic probes for the key biosynthetic enzyme, dehydroquinate synthase
More than thirty years have elapsed since the last truly novel antibacterial drug was released onto the prescription market. Given the rise of super-bugs there is an urgent need to discover new antimicrobial agents. One approach is to look at ways of disrupting bacterial enzymatic pathways; thereby killing bacteria. To this end, Mr Negron studied a specific enzyme within bacteria to understand how the enzyme carries out its reaction. His research has shed light on the mechanism of a vital bacterial enzyme and provides a starting point for the design of future antimicrobial agents.
Associate Professor Emily Parker
Professor Geoff Jameson
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Last updated on Tuesday 04 April 2017